Looped out and perpendicular: Deformation of Watson-Crick base pair associated with actinomycin D binding
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چکیده
منابع مشابه
Looped out and perpendicular: deformation of Watson-Crick base pair associated with actinomycin D binding.
Many anticancer drugs interact directly with DNA to exert their biological functions. To date, all noncovalent, intercalating drugs interact with DNA exclusively by inserting their chromophores into base steps to form elongated and unwound duplex structures without disrupting the flanking base pairs. By using actinomycin D (ActD)-5'-GXC/CYG-5' complexes as examples, we have found a rather unusu...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2002
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.102580399